Examples
- Pharmaceuticals
- Alfatradiol (Ell-Cranell Alpha, Pantostin)
- Dutasteride (Avodart)
- Finasteride (Proscar, Propecia)
- Research chemicals
- Bexlosteride (LY-191,704)
- Epristeride (SKF-105,657, ONO-9302)
- Izonsteride (LY-320,236)
- Lapisteride (CS-891)
- Turosteride (FCE-26,073)
Zinc, azelaic acid, β-sitosterol, certain unsaturated aliphatic fatty acids such as gamma-linolenic acid, alpha-linolenic acid, linoleic acid, and oleic acid, and a variety of polyphenols have been found to inhibit 5α-reductase activity to varying degrees. Among polyphenols, valoneic acid dilactone and gallagyldilactone, two hydrolysable tannins isolated from the heartwood of Shorea laeviforia and in oaks species like the North American white oak (Quercus alba) and European red oak (Quercus robur), shows an inhibitory effect on 5α-reductase. Certain pesticides are able to disturb the sex steroid hormone system and to act as antiandrogens.
Read more about this topic: 5-alpha-reductase Inhibitor
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