4-oxoproline Reductase

In enzymology, a 4-oxoproline reductase (EC 1.1.1.104) is an enzyme that catalyzes the chemical reaction

4-hydroxy-L-proline + NAD+ 4-oxoproline + NADH + H+

Thus, the two substrates of this enzyme are 4-hydroxy-L-proline and NAD+, whereas its 3 products are 4-oxoproline, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-hydroxy-L-proline:NAD+ oxidoreductase. This enzyme is also called hydroxy-L-proline oxidase. This enzyme participates in arginine and proline metabolism.