4-oxalocrotonate Decarboxylase

In enzymology, a 4-oxalocrotonate decarboxylase (EC 4.1.1.77) is an enzyme that catalyzes the chemical reaction

4-oxalocrotonate 2-oxopent-4-enoate + CO₂

Hence, this enzyme has one substrate, 4-oxalocrotonate, and two products, 2-oxopent-4-enoate and CO₂.

This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-oxalocrotonate carboxy-lyase (2-oxopent-4-enoate-forming). This enzyme is also called 4-oxalocrotonate carboxy-lyase. This enzyme participates in 3 metabolic pathways: benzoate degradation via hydroxylation, toluene and xylene degradation, and fluorene degradation.