| 4-hydroxyphenylpyruvate dioxygenase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Homodimer of 4-Hydroxyphenylpyruvate dioxygenase. Red ribbon represents iron-containing catalytic domain (with Fe 2+ represented as red-orange spheres); blue represents the oligomeric domain. Image generated from published structural data | |||||||||
| Identifiers | |||||||||
| EC number | 1.13.11.27 | ||||||||
| CAS number | 9029-72-5 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | |||||||||
| Gene Ontology | |||||||||
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| 4-hydroxyphenylpyruvate dioxygenase | |
|---|---|
| Identifiers | |
| Symbol | HPPD |
| Alt. symbols | HPD; PPD |
| Entrez | 3242 |
| HUGO | 5147 |
| OMIM | 609695 |
| RefSeq | NM_002150 |
| UniProt | P32754 |
| Other data | |
| EC number | 1.13.11.27 |
| Locus | Chr. 12 q24-qter |
4- Hydroxyphenylpyruvate dioxygenase (HPPD) is an Fe(II)-containing non-heme oxygenase that catalyzes the second reaction in the catabolism of tyrosine - the conversion of 4-hydroxyphenylpyruvate into homogentisate. HPPD is an enzyme that is found in nearly all aerobic forms of life. The reaction that HPPD achieves is shown here
Read more about 4-Hydroxyphenylpyruvate Dioxygenase: Enzyme Mechanism, Enzyme Structure, Biologic Function, Disease Relevance, Industrial Relevance
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