4-hydroxybenzaldehyde Dehydrogenase

In enzymology, a 4-hydroxybenzaldehyde dehydrogenase (EC 1.2.1.64) is an enzyme that catalyzes the chemical reaction

4-hydroxybenzaldehyde + NAD+ + H₂O 4-hydroxybenzoate + NADH + 2 H+

The 3 substrates of this enzyme are 4-hydroxybenzaldehyde, NAD+, and H₂O, whereas its 3 products are 4-hydroxybenzoate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 3-hydroxybenzaldehyde:NAD+ oxidoreductase. This enzyme is also called p-hydroxybenzaldehyde dehydrogenase. This enzyme participates in toluene and xylene degradation in bacteria. It is also found in carrots (Daucus carota).