4-hydroxy-3-methylbut-2-enyl Diphosphate Reductase

4-Hydroxy-3-methylbut-2-enyl diphosphate reductase (EC 1.17.1.2, isopentenyl-diphosphate:NADP+ oxidoreductase, LytB, (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate reductase, HMBPP reductase, IspH, LytB/IspH) is an enzyme in the non-mevalonate pathway. It acts upon (E)-4-Hydroxy-3-methyl-but-2-enyl pyrophosphate (or "HMP-PP").

(1) isopentenyl diphosphate + NAD(P)+ + H2O (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+
(2) dimethylallyl diphosphate + NAD(P)+ + H2O (E)-4-hydroxy-3-methylbut-2-en-1-yl diphosphate + NAD(P)H + H+

4-Hydroxy-3-methylbut-2-enyl diphosphate reductase is an iron-sulfur protein that contains either a or a cluster.

Other oxidoreductases (EC 1.15-1.21)
1.15: Acting on superoxide as acceptor
  • Superoxide dismutase
    • SOD1
    • SOD2
    • SOD3
1.16: Oxidizing metal ions
  • Ceruloplasmin
1.17: Acting on CH or CH2 groups
  • Xanthine oxidase
  • Ribonucleotide reductase
  • 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
1.18: Acting on iron-sulfur proteins as donors
  • Nitrogenase
1.19: Acting on reduced flavodoxin as donor
  • Nitrogenase (flavodoxin)
1.20: Acting on phosphorus or arsenic in donors
  • Glutaredoxin
    • GLRX
    • GLRX2
    • GLRX3
    • GLRX5
1.21: Acting on X-H and Y-H to form an X-Y bond
  • Isopenicillin-N synthase
  • B
  • enzm
  • 1.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
    • 10
    • 11
    • 13
    • 14
    • 15-18
  • 2.1
    • 2
    • 3
    • 4
    • 5
    • 6
    • 7
    • 8
  • 2.7.10
  • 2.7.11-12
  • 3.1
      • 3.1.3.48
    • 2
    • 3
    • 4
      • 3.4.21
    • 5
    • 6
    • 7
    • 22
    • 23
    • 24
  • 4.1
    • 2
    • 3
    • 4
    • 5
    • 6
  • 5.1
    • 2
    • 3
    • 4
    • 99
  • 6.1-3
    • 4
    • 5-6
Metabolism - non-mevalonate pathway enzymes
  • DXP synthase
  • DXP reductoisomerase
  • 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
  • 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
  • 4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase
  • 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase
  • 4-hydroxy-3-methylbut-2-enyl diphosphate reductase