4-hydroxy-2-oxoglutarate Aldolase

In enzymology, a 4-hydroxy-2-oxoglutarate aldolase (EC 4.1.3.16) is an enzyme that catalyzes the chemical reaction

4-hydroxy-2-oxoglutarate pyruvate + glyoxylate

Hence, this enzyme has one substrate, 4-hydroxy-2-oxoglutarate, and two products, pyruvate and glyoxylate.

This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming). Other names in common use include 2-oxo-4-hydroxyglutarate aldolase, hydroxyketoglutaric aldolase, 4-hydroxy-2-ketoglutaric aldolase, 2-keto-4-hydroxyglutaric aldolase, 4-hydroxy-2-ketoglutarate aldolase, 2-keto-4-hydroxyglutarate aldolase, 2-oxo-4-hydroxyglutaric aldolase, DL-4-hydroxy-2-ketoglutarate aldolase, hydroxyketoglutarate aldolase, 2-keto-4-hydroxybutyrate aldolase, and 4-hydroxy-2-oxoglutarate glyoxylate-lyase. This enzyme participates in arginine and proline metabolism and glyoxylate and dicarboxylate metabolism.