4-cresol Dehydrogenase (hydroxylating)

In enzymology, a 4-cresol dehydrogenase (hydroxylating) (EC 1.17.99.1) is an enzyme that catalyzes the chemical reaction

4-cresol + acceptor + H₂O 4-hydroxybenzaldehyde + reduced acceptor

The 3 substrates of this enzyme are 4-cresol, acceptor, and H₂O, whereas its two products are 4-hydroxybenzaldehyde and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on CH or CH₂ groups with other acceptors. The systematic name of this enzyme class is 4-cresol:acceptor oxidoreductase (methyl-hydroxylating). Other names in common use include p-cresol–(acceptor) oxidoreductase (hydroxylating), and p-cresol methylhydroxylase. This enzyme participates in toluene and xylene degradation. It has 2 cofactors: FAD, and Cytochrome c.