3-Methylglutaconic Aciduria - Inheritance Patterns

Inheritance Patterns

The inheritance patterns of 3-methylglutaconic aciduria differ depending on the gene involved.

  • Types I and III are inherited in an autosomal recessive pattern, which means two copies of the gene in each cell are altered. Most often, the parents of an individual with an autosomal recessive disorder are carriers of one copy of the altered gene but do not show signs and symptoms of the disorder.
  • Type II is inherited in an X-linked recessive pattern. A condition is considered X-linked if the mutated gene that causes the disorder is located on the X chromosome, one of the two sex chromosomes. In males (who have only one X chromosome), one altered copy of the gene in each cell is sufficient to cause the condition. In females (who have two X chromosomes), a mutation must be present in both copies of the gene to cause the disorder. Males are affected by X-linked recessive disorders much more frequently than females. A striking characteristic of X-linked inheritance is that fathers cannot pass X-linked traits to their sons.
  • The inheritance pattern of 3-methylglutaconic aciduria type IV is unknown.

Read more about this topic:  3-Methylglutaconic Aciduria

Famous quotes containing the words inheritance and/or patterns:

    “A slave who deals wisely will rule over a child who acts shamefully, and will share the inheritance as one of the family.”
    —Bible: Hebrew, Proverbs 17:2.

    “Teasing is universal. Anthropologists have found the same fundamental patterns of teasing among New Zealand aborigine children and inner-city kids on the playgrounds of Philadelphia.”
    —Lawrence Kutner (20th century)