In enzymology, a 3-hydroxy-3-isohexenylglutaryl-CoA lyase (EC 4.1.3.26) is an enzyme that catalyzes the chemical reaction
- 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA 7-methyl-3-oxooct-6-enoyl-CoA + acetate
Hence, this enzyme has one substrate, 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA, and two products, 7-methyl-3-oxooct-6-enoyl-CoA and acetate.
This enzyme belongs to the family of lyases, specifically the oxo-acid-lyases, which cleave carbon-carbon bonds. The systematic name of this enzyme class is 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase (7-methyl-3-oxooct-6-enoyl-CoA-forming). Other names in common use include beta-hydroxy-beta-isohexenylglutaryl CoA-lyase, hydroxyisohexenylglutaryl-CoA:acetatelyase, 3-hydroxy-3-isohexenylglutaryl coenzyme A lyase, 3-hydroxy-3-isohexenylglutaryl-CoA isopentenylacetoacetyl-CoA-lyase, and 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA acetate-lyase.