Schedule
| Date | Time | Opponent# | Rank# | Site | TV | Result | Attendance | |
|---|---|---|---|---|---|---|---|---|
| September 2 | 1:30 PM | Northeastern* | #17 | Lane Stadium • Blacksburg, VA | ESPN360 | W 38-0 | 66,233 | |
| September 9 | 12:00 PM | at North Carolina | #16 | Kenan Memorial Stadium • Chapel Hill, NC | ESPN | W 35-10 | 57,000 | |
| September 16 | 12:00 PM | Duke | #14 | Lane Stadium • Blacksburg, VA | Raycom/LFS | W 36-0 | 66,233 | |
| September 23 | 12:00 PM | Cincinnati* | #11 | Lane Stadium • Blacksburg, VA | ESPNU | W 29-13 | 66,233 | |
| September 30 | 3:30 PM | #24 Georgia Tech | #11 | Lane Stadium • Blacksburg, VA (Battle of the Techs) | ABC | L 27-38 | 66,233 | |
| October 12 | 7:30 PM | at Boston College | #22 | Alumni Stadium • Chestnut Hill, MA (Boston College–Virginia Tech rivalry) | ESPN | L 3-22 | 44,500 | |
| October 21 | 7:00 PM | Southern Miss* | Lane Stadium • Blacksburg, VA | ESPNU | W 36-6 | 66,233 | ||
| October 26 | 7:30 PM | #10 Clemson | Lane Stadium • Blacksburg, VA | ESPN | W 24-7 | 66,233 | ||
| November 4 | 8:00 PM | at Miami | #23 | Miami Orange Bowl • Miami, Florida (Miami–Virginia Tech rivalry) | ABC | W 17-10 | 41,504 | |
| November 11 | 3:30 PM | Kent State* | #20 | Lane Stadium • Blacksburg, VA | ESPNU | W 23-0 | 66,233 | |
| November 18 | 7:00 PM | at #14 Wake Forest | #19 | Groves Stadium • Winston-Salem, NC | ESPN2 | W 27-6 | 36,723 | |
| November 25 | 12:00 PM | Virginia | #17 | Lane Stadium • Blacksburg, VA (Commonwealth Cup) | Raycom/LFS | W 17-0 | 66,233 | |
| December 31 | 8:00 PM | vs. Georgia* | #14 | Georgia Dome • Atlanta, GA (Chick-fil-A Bowl) | ESPN | L 24-31 | 75,406 | |
Read more about this topic: 2006 Virginia Tech Hokies Football Team