2006 National League Championship Series

The 2006 National League Championship Series (NLCS), the second round of the 2006 National League playoffs, began on October 12 and ended on October 19; it was scheduled to begin on October 11, but was postponed a day because of inclement weather. The St. Louis Cardinals upset the heavily-favored New York Mets in seven games to advance to the 2006 World Series against the Detroit Tigers.

The Cardinals and Mets took the series to the limit, reaching the ninth inning of Game 7 tied at 1–1, but the Cardinals benefited from Yadier Molina's two-run home run in the ninth to win the game, 3–1, and earn their second pennant in three years. St. Louis captured the seventeenth NL pennant in club history, placing them one behind the New York/San Francisco Giants and the Brooklyn/Los Angeles Dodgers for the most in the league in the modern era (since 1903). The Cardinals were making their third consecutive appearance in the NLCS; manager Tony La Russa, who led St. Louis to the 2004 pennant and previously won AL titles with the Oakland Athletics from 1988–90, became the first manager in history to win multiple pennants in both leagues.

The Mets had defeated the Los Angeles Dodgers three games to none in the NL Division Series, while the Cardinals had defeated the San Diego Padres three games to one. The Mets had home-field advantage due to their better record in the regular season (the Mets were 97–65, the Cardinals 83–78). The Mets and Cardinals previously met in the 2000 NLCS, which the Mets won in five games.