Schedule
| Date | Time | Opponent# | Rank# | Site | TV | Result | Attendance | |
|---|---|---|---|---|---|---|---|---|
| September 2, 2006 | 12:00 PM | Vanderbilt* | #14/15 | Michigan Stadium • Ann Arbor, MI | ESPN | W 27–7 | 109,668 | |
| September 9, 2006 | 12:00 PM | Central Michigan* | #10/13 | Michigan Stadium • Ann Arbor, MI | ESPN+ | W 41–17 | 108,712 | |
| September 16, 2006 | 3:30 PM | at #2/3 Notre Dame* | #11/13 | Notre Dame Stadium • Notre Dame, IN (Rivalry) | NBC | W 47–21 | 80,795 | |
| September 23, 2006 | 12:00 PM | Wisconsin | #6/6 | Michigan Stadium • Ann Arbor, MI | ESPN | W 27–13 | 110,058 | |
| September 30, 2006 | 8:00 PM | Minnesota | #6/6 | Hubert H. Humphrey Metrodome • Minneapolis, MN (Little Brown Jug) | ESPN | W 28–14 | 50,805 | |
| October 7, 2006 | 4:30 PM | Michigan State | #6/6 | Michigan Stadium • Ann Arbor, MI (Paul Bunyan Trophy) | ESPN | W 31–13 | 111,349 | |
| October 14, 2006 | 8:00 PM | at Penn State | #4/5 | Beaver Stadium • University Park, PA | ABC | W 17–10 | 110,007 | |
| October 21, 2006 | 3:30 PM | #NR/23 Iowa | #2/3 | Michigan Stadium • Ann Arbor, MI | ABC | W 20–6 | 110,923 | |
| October 28, 2006 | 12:00 PM | Northwestern | #2/3 | Michigan Stadium • Ann Arbor, MI | ESPN | W 17–3 | 109,114 | |
| November 4, 2006 | 12:00 PM | Ball State* | #2/2 | Michigan Stadium • Ann Arbor, MI | ESPNU | W 34–26 | 109,359 | |
| November 11, 2006 | 3:30 PM | at Indiana | #2/2 | Memorial Stadium • Bloomington, IN | ESPN | W 34–3 | 42,320 | |
| November 18, 2006 | 3:30 PM | at #1/1 Ohio State | #2/2 | Ohio Stadium • Columbus, OH (The Game) | ABC | L 42–39 | 105,708 | |
| January 1, 2007 | 5:00 PM | vs. #8/7 USC* | #3/3 | Rose Bowl • Pasadena, CA (Rose Bowl) | ABC | L 32–18 | 93,852 | |
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