Semi-finals
- (week ending 30th July)
Unlike earlier rounds, matches from now on will be played on neutral grounds. Huddersfield have the chance to win the Cup for the first time in 1953 when they beat this year's final opponents St Helens.
| July 29, 2006 | St. Helens | 50–0 | Hull Kingston Rovers | Galpharm Stadium, Huddersfield Attendance: 12,868 Referee/s: Karl Kirkpatrick |
| Jamie Lyon (18), Willie Talau (8), Jon Wilkin (8), Vinnie Anderson (4), Ade Gardner (4), Sean Long (4), Paul Wellens (4) | (Report) |
| July 30, 2006 | Leeds Rhinos | 12–30 | Huddersfield Giants | Odsal Stadium, Bradford Attendance: 12,574 |
| Scott Donald (4), Willie Poching (4), Kevin Sinfield (2) | (Report) | Michael De Vere (14), Stuart Donlan (8), Chris Nero (8) |
Read more about this topic: 2006 Challenge Cup