Round 5
- (week ending 21st May)
No new teams enter at this stage. In this round the matches chosen for transmission were at St Helens and Widnes.
| Tie no | Home team | Score | Away team |
|---|---|---|---|
| 1 | Salford City Reds | 16-4 | Wigan Warriors |
| 2 | Huddersfield Giants | 38-4 | York City Knights |
| 3 | Widnes Vikings | 16-34 | Catalans Dragons |
| 4 | Leeds Rhinos | 66-0 | Rochdale Hornets |
| 5 | Hull Kingston Rovers | 44-12 | Featherstone Rovers |
| 6 | Harlequins | 82-8 | Barrow Raiders |
| 7 | Warrington Wolves | 46-2 | Whitehaven |
| 8 | St. Helens | 42-18 | Bradford Bulls |
Read more about this topic: 2006 Challenge Cup