Quarter-finals
- (week ending 4th June)
In this round the matches chosen for transmission were at Hull KR and Leeds. Hull KR pulled off a major surprise when they beat Superleague team Warrington Wolves.
| June 4, 2006 | Leeds Rhinos | 36–18 | Harlequins | Headingley, Leeds Referee/s: Karl Kirkpatrick |
| Danny Williams (12), Scott Donald (8), Kevin Sinfield (8), Danny McGuire (4), Willie Poching (4) | (Report) | Luke Dorn (4), Tyrone Smith (4), Pat Weisner (4), Michael Worrincy (4), Rob Purdham (2) |
| June 4, 2006 | Hull Kingston Rovers | 40–36 | Warrington Wolves | Craven Park, Hull Referee/s: Steve Ganson |
| Byron Ford (12), Gareth Morton (12), Makali Aizue (4), Dwayne Barker (4), Ben Cockayne (4), Jon Goddard (4) | (Report) | Chris Bridge (8), Henry Fa'afili (8), Logan Swann (8), Martin Gleeson (4), Stuart Reardon (4), Michael Sullivan (4) |
| June 4, 2006 | Huddersfield Giants | 44–14 | Salford City Reds | Galpharm Stadium, Huddersfield Referee/s: Ashley Klein |
| Michael De Vere (12), Paul March (8), Chris Nero (8), Robbie Paul (8), Martin Aspinwall (4), Brad Drew (4) | (Report) | David Hodgson (10), Aaron Moule (4) |
| June 3, 2006 | St. Helens | 56–10 | Catalans Dragons | Knowsley Road, St. Helens Referee/s: Richard Silverwood |
| Ade Gardner (12), Paul Anderson (8), Vinnie Anderson (4), Sean Long (4), Jamie Lyon (4), Leon Pryce (4), Jon Wilkin (4) | (Report) | Stacey Jones (4), Justin Murphy (4), Laurent Frayssinous (2) |
Read more about this topic: 2006 Challenge Cup