The 2001 American League Division Series (ALDS), the opening round of the 2001 American League playoffs, began on Tuesday, October 9, and ended on Monday, October 15, with the champions of the three AL divisions—along with a "wild card" team—participating in two best-of-five series. The teams were:
- (1) Seattle Mariners (Western Division champion, 116–46) vs. (3) Cleveland Indians (Central Division champion, 91–71): Mariners win series, 3–2.
- (2) New York Yankees (Eastern Division champion, 95–65) vs. (4) Oakland Athletics (Wild Card, 102–60): Yankees win series, 3–2.
The higher seed (in parentheses) had the home field advantage (Games 1, 2 and 5 at home), which was determined by playing record. Although the team with the best record was normally intended to play the wild card team, the Mariners played the Indians, rather than the wild card Athletics, because the Mariners and Athletics are in the same division.
The Seattle Mariners and New York Yankees went on to meet in the AL Championship Series (ALCS). The Yankees became the American League champion, and lost to the National League champion Arizona Diamondbacks in the 2001 World Series.
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