In Transportation
- The Volkswagen 181
- The wing area of a Boeing 757 airplane is 181.25 m (1,951 sq ft)
- Lufthansa Flight 181, which was hijacked on October 13, 1977
- TAM Airlines Flight 3054 with 181 passengers aboard crashed upon landing in São Paulo on July 17, 2007
- London Buses route 181
- 181 Union City-New York, a New Jersey Transit bus route from New Jersey to New York
- The Córas Iompair Éireann CIE 181 Class diesel locomotives, and numbered B181 to B192, built by General Motors Electro-Motive Division (EMD) in 1966
- East 181st Avenue, a light rail station on the MAX Blue Line in Gresham, Oregon
- New York City Subway stations in Manhattan:
- 181st Street (IND Eighth Avenue Line), at Fort Washington Avenue served by the A train
- 181st Street (IRT Broadway – Seventh Avenue Line), at St. Nicholas Avenue served by the 1 train
- 181st Street (Manhattan)
- Oregon Route 229, also known as the Siletz Highway No. 181
- List of highways numbered 181 include:
- U.S. Route 181 runs from San Antonio to Corpus Christi, Texas
- Alabama State Route 181
- Arizona State Route 181
- Connecticut Route 181
- K-181 (Kansas highway)
- Massachusetts Route 181
- M-181 (Michigan highway) (former)
- Missouri Route 181
- New Jersey Route 181
- Ohio State Route 181
- Pennsylvania Route 181
- Tennessee State Route 181
- Utah State Route 181
- Utah State Route 181A (former)
- Virginia State Route 181
- Washington State Route 181
- Wisconsin Highway 181
- Puerto Rico Highway 181
- SP-181, São Paulo, Brazil
- M181 motorway, Scunthorpe, England
- Route 181 (Japan) connects Tsuyama, Okayama and Yonago, Tottori
- Pulau Indah Expressway Federal Route 181 in Klang Valley, Selangor, Malaysia
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